Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential novel antileishmanial agents

Glucan and Tuftsin - Potential Antileishmanial Agents

Green Chemical Synthesis and Biological Evaluation of Novel N-substituted Rhodanine Derivatives as Potential Antifungal Agents

Background and purpose: In medicinal chemistry, molecules containing rhodanine(2-thiazolidine-4-one) ring as a magic multifunctional privileged structural and functional scaffold show a broad range of potent pharmacological properties containing anti-microbial, antiviral, anti-diabetic, and anti-convulsant effects. Evidence suggests that the activity of the rhodanine derivative correlates with ...

9-Anilinoacridines as potential antileishmanial agents.

A number of 1'-substituted 9-anilinoacridines were evaluated for their activities against promastigote and amastigote forms of Leishmania major and for their toxicities to human Jurkat leukemia cells. Several compounds possessing 1'-NH-alkyl substituents produced more than 80% growth inhibition of macrophage-infected L. major amastigotes at or below a concentration of 1 microM. 1'-Hexylamino-9-...

N-cinnamoylated aminoquinolines as promising antileishmanial agents.

A series of cinnamic acid conjugates of primaquine and chloroquine were evaluated for their in vitro antileishmanial activities. Although primaquine derivatives had modest activity, chloroquine conjugates exhibited potent activity against both promastigotes (50% inhibitory concentration [IC50] = 2.6 to 21.8 μM) and intramacrophagic amastigotes (IC50 = 1.2 to 9.3 μM) of Leishmania infantum. Both...

Nonlinear Exploratory Data Analysis Applied to Seismic Signals

This paper compares three unsupervised projection methods: Principal Component Analysis (PCA), which is linear, Self-Organizing Map (SOM) and Curvilinear Component Analysis (CCA), which are both nonlinear. Performance comparison of the three methods is made on a set of seismic data recorded on Stromboli that includes three classes of signals: explosion-quakes, landslides, and microtremors. The ...